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P. gingivalis LPS induced cell proliferation of both C 3 H/HeN and C 3 H/HeJ B cells, accompanied by the induction of tyrosine phosphorylation of selected proteins that included 25 kDa protein (p25). In contrast, Escherichia coli LPS activated only C 3 H/HeN B cells to proliferate and to induce tyrosine phosphorylation of p25. In order to characterize p25, P. gingivalis LPS-activated B cell lysates were separated by two-dimensional gel electrophoresis (2D-PAGE). Two out of 8 spots of the candidates of p25 separated by 2D-PAGE were identified as Ran (Ras-like nuclear protein) by peptide mass fingerprinting with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Western blotting analysis revealed that Ran existed as at least 4 spots in B cells with and without LPS stimulation. However, total amounts and the amount of the most acidic spot of Ran apparently increased by P. gingivalis LPS stimulation. 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Porphyromonas gingivalis LPSによるマウスB細胞の増殖反応にかかわる25kDaチロシンリン酸化タンパク質の解析
https://iwatemed.repo.nii.ac.jp/records/1456
https://iwatemed.repo.nii.ac.jp/records/1456b3633f8c-899f-483f-9385-94cac72bf415
名前 / ファイル | ライセンス | アクション |
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KJ00004579609 (1.2 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-04-25 | |||||
タイトル | ||||||
タイトル | Porphyromonas gingivalis LPSによるマウスB細胞の増殖反応にかかわる25kDaチロシンリン酸化タンパク質の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Analysis of 25 kDa tyrosine phosphorylated proteins in Porphyromonas gingivalis LPS-induced mouse B cell proliferation | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
下山, 佑
× 下山, 佑 |
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著者名よみ |
シモヤマ, ユウ
× シモヤマ, ユウ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 32, 号 1, p. 46-56, 発行日 2007-04-25 |