WEKO3
アイテム
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The experimental study demonstrated FDG uptake was higher in faster-growing rather than in slower-growing tumors. These findings show FDG accumulation exhibits cell cycle dependency. However, the precise mechanism remains to be elucidated. In this study, the relationship between FDG uptake and the cell cycle phase in HeLa S3 cells, as well as how they compare to the conventional tracer ^67Ga citrate (Ga) with single photon emission tomography (SPECT) was assessed. Synchronization of HeLa S3 cells was accomplished via a double thymidine block. The uptake of FDG and Ga was determined after cell cycle synchronization. The glucose transporter was independently evaluated for the level of its Glut 1 glucose transporter membrane protein. FDG uptake in HeLa S3 cells was significantly higher in the early S phase and G_2/M phase compared to the G_1 phase. In addition, Ga uptake was higher in the G_2/M phase. Immunochemical assays for the Glut 1 transporter showed an increase in membrane expression within S phase cells. It has been concluded that cell cycle dependency is reflected in the uptake of FDG and Ga, seen during PET or SPECT imaging of tumor tissue. These results reveal tumor proliferative activity, and can assist in evaluating a therapeutic response. 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HeLa S3細胞に対するFDGと^67Ga citrate集積の細胞周期依存性
https://iwatemed.repo.nii.ac.jp/records/1661
https://iwatemed.repo.nii.ac.jp/records/166171fea566-5fcb-4fb2-82be-0ca581ab79e1
名前 / ファイル | ライセンス | アクション |
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KJ00002373624 (752.8 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-12-24 | |||||
タイトル | ||||||
タイトル | HeLa S3細胞に対するFDGと^67Ga citrate集積の細胞周期依存性 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cell cycle dependency of FDG and ^67Ga citrate uptake in HeLa S3 cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
守口, 斉
× 守口, 斉× 小豆島, 正典 |
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著者名よみ |
モリグチ,ヒトシ,ショウズシマ,マサノリ
× モリグチ,ヒトシ,ショウズシマ,マサノリ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 27, 号 3, p. 270-278, 発行日 2002-12-24 |