Department of Orthodontics, School of Dentistry, Iwate Medical University
Department of Orthodontics, School of Dentistry, Iwate Medical University
Department of Orthodontics, School of Dentistry, Iwate Medical University
Department of Orthodontics, School of Dentistry, Iwate Medical University
Department of Orthodontics, School of Dentistry, Iwate Medical University
Department of Orthodontics, School of Dentistry, Iwate Medical University
With recently prevailed knowledge and information on orthodontic treatment as well as improved awareness about dental health and aesthetic concerns, the proportion of adult female orthodontic patients has tended to increase yearly. The decreases of bone density in females forty and older are known. Although several reports have investigated the possible relationship between osteoporosis and the alveolar bone, we could not find a report concerning the tooth movement in relation to this disease. In this study, we confirmed that tooth movement was experimentally induced by inserting a gum ring for orthodontic treatment onto the molar site of normal and osteoporotic rats 12 weeks postpartum. The histological study of the alveolar bone was performed with immunohistological staining using TGF- β 1 antibody as a primary antibody. As a result, we found that TGF-β 1 is induced by orthodontic force and acts on osteoblasts and osteoclasts in the alveolar bone and ultimately induces a reconstruction of alveolar bone through activation of both bone formation and resorption. This also occurred even in the case of osteoporosis, however, an enhanced bone resorption and delayed initiation of bone formation was suggested in the osteoporotic group.
骨粗鬆症ラットにおける歯槽骨に対する歯の移動の影響
KJ00002373750
(2.27MB)
トップページ
岩手医科大学リポジトリ運用指針