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The organism possesses a number of pathogenic properties, however, the adhesive mechanism that mediates the initial process of S. anginosus infection to oral mucosal epithelial cells remains to be elucidated. In this study, the adhesive abilities of S. anginosus to mucosal epithelial cells of a human larynx carcinoma cell line (HEp-2 cells) and a gingival epithelial cell line (GE1 cells) as well as the immobilized fibronectin were investigated. The results indicated that S. anginosus can adhere to both mucosal epithelial cells as other oral streptococci do, and that the adhesive ability could be ascribable to mainly its fibronectin-mediated adherence to the mucosal epithelial cells. It was also indicated that the adhesive ability to HEp-2 cells of the S. anginosus isolates from oral cancer tissues was significantly higher than that of the isolates from the plaque sample of healthy subjects. Although the cell-surface expression of fibronectin in HEp-2 cells was augmented by the bacterial adhesion itself and the autocrine activation of TGF-β 1 induced by the bacterial adhesion, the addition of exogenous fibronectin (10nM) enhanced the S. anginosus adherence to HEp-2 cells. Furthermore, the pretreatments with fibronectin of the bacterial cells as well as HEp-2 cells enhanced the S. anginosus adherence, and the enhancements were abrogated by the addition of anti-fibronectin antibodies, suggesting the coexistence of a direct adhesion of S. anginosus to the fibronectin of HEp-2 cell surfaces and another fibronectin-mediated adhesion mechanism involving a fibronectin bridge between the S. anginosus fibronectin-binding molecule(s) and the integrins of HEp-2 cells. Moreover, the adhesive ability of the oral cancer isolates of S. anginosus was markedly higher than those of the plaque sample isolates and of the laboratory strain of S. anginosus. Taken together, the present findings suggest that S. anginosus could adhere to mucosal epithelial cells via multiple adhesion mechanisms, and the adhesive ability to fibronectin could be involved in the pathogenicity of S. anginosus, leading to the onset of oral squamous cell carcinoma.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pathogenesis and Control of Oral Diseases, Division of Oral Microbiology and Immunology, Iwate Medical University School of Dentistry"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部口腔病因病態制御学講座・口腔微生物学免疫学分野"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2009-12-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00005928013.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "KJ00005928013", "url": "https://iwatemed.repo.nii.ac.jp/record/1903/files/KJ00005928013.pdf"}, "version_id": "a9fa5db3-0402-4a62-9c9a-4332f36c94ed"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Streptococcus anginosus", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adhesion mechanism", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mucosal epithelial cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fibronectin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Streptococcus anginosusの粘膜上皮細胞への付着機構", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Streptococcus anginosusの粘膜上皮細胞への付着機構"}, {"subitem_title": "Adhesion mechanism of Streptococcus anginosus to mucosal epithelial cells", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["128", "459"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1903", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-12-20"}, "publish_date": "2009-12-20", "publish_status": "0", "recid": "1903", "relation": {}, "relation_version_is_last": true, "title": ["Streptococcus anginosusの粘膜上皮細胞への付着機構"], "weko_shared_id": 5}
Streptococcus anginosusの粘膜上皮細胞への付着機構
https://iwatemed.repo.nii.ac.jp/records/1903
https://iwatemed.repo.nii.ac.jp/records/190367e2a6c7-d44e-447d-986c-044f2e07fc85
名前 / ファイル | ライセンス | アクション |
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KJ00005928013 (1.6 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2009-12-20 | |||||
タイトル | ||||||
タイトル | Streptococcus anginosusの粘膜上皮細胞への付着機構 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Adhesion mechanism of Streptococcus anginosus to mucosal epithelial cells | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
古玉, 芳豊
× 古玉, 芳豊 |
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著者名よみ |
コダマ, ヨシトヨ
× コダマ, ヨシトヨ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 34, 号 3, p. 83-96, 発行日 2009-12-20 |