WEKO3
アイテム
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To elucidate the functional role in innate immunity in gingival crevices, the SLPI production from a gingival epithelial cell line, GE1, with or without the stimulation of Porphyromonas gingivalis lyophilized whole cells (Pg-WC) and the lipopolysaccharides (Pg-LPS), and the inhibitory effect on P. gingivalis proteases were investigated. The unstimulated GE1 cells showed low levels of SLPI mRNA expression, which was augmented by the stimulation with Pg-LPS as well as Pg-WC. The augmentation of SLPI mRNA expression in GE1 cells was accompanied by the inductions of IL-6, TNF-α and IL-1β mRNA expressions. Although IL-6 could induce macrophages to produce SLPI, the kinetics analyses suggested that the augmentation of SLPI production in GE1 cells could not be a second response to the IL-6 induced by the stimulant, but a direct response by the P. gingivalis antigens. Further experiments using rSLPI indicated that SLPI showed a direct inhibitory effect on the P. gingivalis protease of Lys-gingipain. Thus, it was suggested that gingival epithelial cells could be a substantial producer of SLPI that functions inhibitory to the pathogenic P. gingivalis protease in gingival crevices. It was also suggested that the SLPI production could increase in response to P. gingivalis through the stimulation with its pathogenic constituents.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pathogenesis and Control of Oral Diseases, Division of Oral Microbiology and Immunology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部口腔病因病態制御学講座口腔微生物学免疫学分野"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2010-04-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00006253148.pdf", "filesize": [{"value": "870.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 870300.0, "url": {"label": "KJ00006253148", "url": "https://iwatemed.repo.nii.ac.jp/record/1930/files/KJ00006253148.pdf"}, "version_id": "fe254dcf-7843-4eb4-9b3d-c3a6578db4d2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "secretory leukocyte protease inhibitor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gingival epithelial cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "inhibitory effect", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Porphyromonas gingivalis infection", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "分泌型白血球プロテアーゼインヒビターによる歯肉上皮細胞のPorphyromonas gingivalis感染制御", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "分泌型白血球プロテアーゼインヒビターによる歯肉上皮細胞のPorphyromonas gingivalis感染制御"}, {"subitem_title": "Secretory leukocyte protease inhibitor (SLPI) production from gingival epithelial cells and its inhibitory effect against Porphyromonas gingivalis infection", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["128", "461"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1930", "pubdate": {"attribute_name": "公開日", "attribute_value": "2010-04-23"}, "publish_date": "2010-04-23", "publish_status": "0", "recid": "1930", "relation": {}, "relation_version_is_last": true, "title": ["分泌型白血球プロテアーゼインヒビターによる歯肉上皮細胞のPorphyromonas gingivalis感染制御"], "weko_shared_id": 5}
分泌型白血球プロテアーゼインヒビターによる歯肉上皮細胞のPorphyromonas gingivalis感染制御
https://iwatemed.repo.nii.ac.jp/records/1930
https://iwatemed.repo.nii.ac.jp/records/19301c55add9-cc2b-4de4-b073-95f58f79558a
名前 / ファイル | ライセンス | アクション |
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KJ00006253148 (870.3 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2010-04-23 | |||||
タイトル | ||||||
タイトル | 分泌型白血球プロテアーゼインヒビターによる歯肉上皮細胞のPorphyromonas gingivalis感染制御 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Secretory leukocyte protease inhibitor (SLPI) production from gingival epithelial cells and its inhibitory effect against Porphyromonas gingivalis infection | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
石河, 太知
× 石河, 太知 |
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著者名よみ |
イシカワ, タイチ
× イシカワ, タイチ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 35, 号 1, p. 29-41, 発行日 2010-04-23 |