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However, in the previous studies, satellite cells surrounding ganglion cells have no been studied. The present study aimed to reveal the effects of ATP on ganglion and satellite cells, to this end we observed intracellular Ca^\u003c2+\u003e ion concentration ([Ca^\u003c2+\u003e]_i) change in DRG which kept structural integrities. DRG were taken out from immature (E20D) and mature (8W) rats. The [Ca^\u003c2+\u003e]_i changes during ATP stimulation were analysed by a confocal microscope. In immature and mature DRG, both ganglion and satellite cells responded to ATP. The ATP-induced [Ca^\u003c2+\u003e]_i increase of ganglion cells was rapid, and the decline was slow, while the satellite cell responses were spike-like. Only 1-3% of ganglion cells showed ATP-induced [Ca^\u003c2+\u003e]_i changes, and about 40% of satellite cells responded. Based on the dependence of the response on presence of extracellular Ca^\u003c2+\u003e and the agonist stimulations, ganglion and satellite cells possessed P2X and/or P2Y. There were no significant differences on ganglion cell responses between immature and mature DRG. In immature satellite cells, the response was single-shot, while mature satellite cells showed oscillatory fluctuation. Present results indicate that population of ganglion cells responding to ATP was low. Previous studies might confuse responses of satellite cells and those of ganglion cells. Oscillatory fluctuations appeared in mature satellite cells indicated a change of intracellular signalling mechanism during postnatal development.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Dental Anesthesiology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科麻酔学講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2005-04-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002592202.pdf", "filesize": [{"value": "749.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 749300.0, "url": {"label": "KJ00002592202", "url": "https://iwatemed.repo.nii.ac.jp/record/1266/files/KJ00002592202.pdf"}, "version_id": "08ccef8b-add6-40db-854c-9c626d98fd76"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "DRG", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Satellite cell", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ganglion cell", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "P2 receptor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Calcium", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "未熟及び成熟ラット脊髄後根神経節細胞のATP刺激に対する細胞内カルシウムイオン濃度変動の画像解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "未熟及び成熟ラット脊髄後根神経節細胞のATP刺激に対する細胞内カルシウムイオン濃度変動の画像解析"}, {"subitem_title": "Imaging analysis of effect of ATP on intracellular calcium ion dynamics of dorsal root ganglia in immature and mature rats", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["118", "378"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1266", "pubdate": {"attribute_name": "公開日", "attribute_value": "2005-04-25"}, "publish_date": "2005-04-25", "publish_status": "0", "recid": "1266", "relation": {}, "relation_version_is_last": true, "title": ["未熟及び成熟ラット脊髄後根神経節細胞のATP刺激に対する細胞内カルシウムイオン濃度変動の画像解析"], "weko_shared_id": 5}
未熟及び成熟ラット脊髄後根神経節細胞のATP刺激に対する細胞内カルシウムイオン濃度変動の画像解析
https://iwatemed.repo.nii.ac.jp/records/1266
https://iwatemed.repo.nii.ac.jp/records/1266c900ca18-c7b0-4ce2-ab77-f55345fd95d5
名前 / ファイル | ライセンス | アクション |
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KJ00002592202 (749.3 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2005-04-25 | |||||
タイトル | ||||||
タイトル | 未熟及び成熟ラット脊髄後根神経節細胞のATP刺激に対する細胞内カルシウムイオン濃度変動の画像解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Imaging analysis of effect of ATP on intracellular calcium ion dynamics of dorsal root ganglia in immature and mature rats | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
鍋島, 謙一
× 鍋島, 謙一 |
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著者名よみ |
ナベシマ, ケンイチ
× ナベシマ, ケンイチ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 30, 号 1, p. 1-11, 発行日 2005-04-25 |