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Materials and Methods : Seventy-two male Wistar rats (7 weeks old) were divided into four groups for this study. In Group A, molar teeth were left intact. In Group B, maxillary first molar teeth were extracted. In Group C, maxillary first and second molar teeth were extracted. In Group D, maxillary first, second and third molar teeth were extracted. A series of spatial memory tasks were performed in an 8 -arm radial maze at 1, 4 and 7 weeks for all four groups. Following completion of this task period, levels of pyramidal cells and TrkB positive cells were observed. Results : At 7 weeks, the results showed that Groups B, C and D exhibited significant behavioral dysfunction compared to group A, yet behavioral dysfunction was more remarkable the greater the number of lost molar teeth. Group B, C and D also showed a significant decrease in the number of hippocampal pyramidal cells and TrkB positive cells in CA1, CA3 and CA4. Conclusions : In conclusion, since the effects of experimental tooth extractions in rats caused decreased amounts of TrkB mRNA positive cells in hippocampal pyramidal cells, spatial learning and memory were affected. As the number of teeth lost increased, higher brain function decreased.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Removable Prosthodontics, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科補綴学第一講座"}, {"subitem_text_value": "岩手医科大学歯学部歯科補綴学第一講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2005-04-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002592203.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "KJ00002592203", "url": "https://iwatemed.repo.nii.ac.jp/record/1267/files/KJ00002592203.pdf"}, "version_id": "575bffd6-aa31-4217-afa6-4c60de1478b5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "molar tooth loss", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "higher brain function", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "8-arm radial maze", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hippocampal pyramidal cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "TrkB mRNA positive cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "TrkB mRNA発現からみたラット臼歯喪失歯数の多寡と高次脳機能の関連", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "TrkB mRNA発現からみたラット臼歯喪失歯数の多寡と高次脳機能の関連"}, {"subitem_title": "The Relationship Between the Number of Molar Teeth Lost and Higher Brain Function in Rats Using an Expression of TrkB mRNA", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["120", "378"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1267", "pubdate": {"attribute_name": "公開日", "attribute_value": "2005-04-25"}, "publish_date": "2005-04-25", "publish_status": "0", "recid": "1267", "relation": {}, "relation_version_is_last": true, "title": ["TrkB mRNA発現からみたラット臼歯喪失歯数の多寡と高次脳機能の関連"], "weko_shared_id": 5}
TrkB mRNA発現からみたラット臼歯喪失歯数の多寡と高次脳機能の関連
https://iwatemed.repo.nii.ac.jp/records/1267
https://iwatemed.repo.nii.ac.jp/records/126762640e6b-6328-4c35-b2d4-551c7a1406cc
名前 / ファイル | ライセンス | アクション |
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KJ00002592203 (1.0 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2005-04-25 | |||||
タイトル | ||||||
タイトル | TrkB mRNA発現からみたラット臼歯喪失歯数の多寡と高次脳機能の関連 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The Relationship Between the Number of Molar Teeth Lost and Higher Brain Function in Rats Using an Expression of TrkB mRNA | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
山崎, 薫子
× 山崎, 薫子× 虫本, 栄子 |
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著者名よみ |
ヤマザキ, カオルコ
× ヤマザキ, カオルコ× ムシモト, エイコ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 30, 号 1, p. 12-22, 発行日 2005-04-25 |