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Immunohistochemistry was performed for E-cadherin, α-catenin and β-catenin in the primary lesions of 11 oral squamous cell carcinomas, and 36 tissues of 18 metastatic foci. The PCNA (proliferative cell nuclear antigen) labeling index was calculated as the percent of immunostain-positive cells to anti-PCNA antibody. Immunostaining of adhesion molecules was categorized as one of three types: preserved, reduced, and lost compared with that in normal oral epithelium. These three adhesion molecules were clearly expressed in the cell-cell contact sites of normal oral epithelium. In the expression of E-cadherin, 8 primary tumors showed reduced type (72.7%), which was the highest ratio. In contrast, in metastatic foci, 25 tumors showed lost-type as the highest (69.4%). Furthermore, in metastatic focus, the expression of E-cadherin was significantly (ANOVA, p\u003c0.05) decreased, and that of β-catenin was also decreased as the tumor expanded in the lymph node. However, the expression of α-catenin did not change with tumor progression. Although the PCNA labeling index in metastatic foci was significantly lower than that in primary tumors (Student t-test, p\u003c0.01), it increased as the tumor advanced in the lymph node. In metastatic foci, as the expression of E-cadherin reduced, the PCNA labeling index was increased conversely. In conclusion, in metastatic oral squamous cell carcinoma of the lymph node, reduction of E-cadherin was involved in the growth and migration of oral squamous cell carcinoma.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Oral Pathology, School of Dentistry , Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部口腔病理学講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2006-04-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004302029.pdf", "filesize": [{"value": "3.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 3900000.0, "url": {"label": "KJ00004302029", "url": "https://iwatemed.repo.nii.ac.jp/record/1361/files/KJ00004302029.pdf"}, "version_id": "9c1d1fae-3565-489e-b0d9-7a535bb10f62"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "oral squamous cell carcinoma", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "metastatic focus", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intercellular adhesion molecules", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cell proliferative activity", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "口腔扁平上皮癌の頸部リンパ節転移巣における細胞増殖活性と細胞間接着分子の発現に関する病理学的研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "口腔扁平上皮癌の頸部リンパ節転移巣における細胞増殖活性と細胞間接着分子の発現に関する病理学的研究"}, {"subitem_title": "Pathological study of cell proliferative activity and expression of intercellular adhesion molecules in metastatic focus of oral squamous cell carcinoma in lymph node", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["130", "382"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1361", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-04-25"}, "publish_date": "2006-04-25", "publish_status": "0", "recid": "1361", "relation": {}, "relation_version_is_last": true, "title": ["口腔扁平上皮癌の頸部リンパ節転移巣における細胞増殖活性と細胞間接着分子の発現に関する病理学的研究"], "weko_shared_id": 5}
口腔扁平上皮癌の頸部リンパ節転移巣における細胞増殖活性と細胞間接着分子の発現に関する病理学的研究
https://iwatemed.repo.nii.ac.jp/records/1361
https://iwatemed.repo.nii.ac.jp/records/1361c82ae504-c0bd-4145-afd5-8c2fb7f2753b
名前 / ファイル | ライセンス | アクション |
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KJ00004302029 (3.9 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-25 | |||||
タイトル | ||||||
タイトル | 口腔扁平上皮癌の頸部リンパ節転移巣における細胞増殖活性と細胞間接着分子の発現に関する病理学的研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathological study of cell proliferative activity and expression of intercellular adhesion molecules in metastatic focus of oral squamous cell carcinoma in lymph node | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
古屋, 出
× 古屋, 出 |
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著者名よみ |
フルヤ, イズル
× フルヤ, イズル |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 31, 号 1, p. 19-31, 発行日 2006-04-25 |