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One drug used in psychosedation is midazolam, which is known to have a strong amnestic effect. In the current research, I sought to clarify whether the bispectral index (BIS) using EEC analysis can be used for assessment of optimal sedation in psychosedation, and what effects midazolam has on the cerebrum\u0027s mechanism of memory. The subjects were 17 healthy adult volunteers. Intravenous sedation involved a single administration of 0.06mg/kg midazolam, or 6mg/kg/h propofol, administered for 5 minutes and then continuously administered for 25 minutes at 3mg/kg/h. For nitrous oxide inhalation sedation, 10-30% nitrous oxide was used. Clinical sedation and the BIS were measured in a variety of circumstances. To examine the effects of midazolam on the central nervous system, changes in brain oxygen consumption in visual memory tasks were assessed through observing changes in areas of brain activation using 3 T fMRI. With intravenous sedation using midazolam or propofol, the BIS decreased immediately after drug administration, and the BIS at which optimal sedation was clinically determined was about 65. In contrast, no decrease in the BIS was noted with nitrous oxide inhalation sedation. In observing areas of brain activation by fMRI, the oxygen consumption mainly of visual cortices in the occipital lobe increased as a result of stimulation by visual memory tasks. Regardless of the amnestic effect midazolam produced in subjects, it did not suppress activation of the visual cortices in the occipital lobe. In intravenous sedation using midazolam or propofol, the BIS is effective in determining optimal sedation, and appropriate perioperative management can be performed using the BIS. However, in nitrous oxide inhalation sedation it appears that the BIS cannot be used to monitor levels of sedation. Amnestic action by midazolam is assumed to occur not through inhibition of pathways from visual cells to visual cortices, but through inhibition of the higher central nervous system.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Dental Anesthesiology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科麻酔学講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2006-04-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00004302030.pdf", "filesize": [{"value": "970.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 970800.0, "url": {"label": "KJ00004302030", "url": "https://iwatemed.repo.nii.ac.jp/record/1362/files/KJ00004302030.pdf"}, "version_id": "17b3afa2-61c6-4691-8b3e-d5d92f6f35d7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "BIS", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "functional-MRI", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intravenous/inhalation sedation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "memory", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "regional cerebral blood flow", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ミダゾラムによる鎮静時のBispectral Index変化とfMRIによる脳機能画像の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ミダゾラムによる鎮静時のBispectral Index変化とfMRIによる脳機能画像の検討"}, {"subitem_title": "Changes to the bispectral index and regional cerebral blood flow in a sedative state, caused by midazolam administration", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["118", "382"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1362", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-04-25"}, "publish_date": "2006-04-25", "publish_status": "0", "recid": "1362", "relation": {}, "relation_version_is_last": true, "title": ["ミダゾラムによる鎮静時のBispectral Index変化とfMRIによる脳機能画像の検討"], "weko_shared_id": 5}
ミダゾラムによる鎮静時のBispectral Index変化とfMRIによる脳機能画像の検討
https://iwatemed.repo.nii.ac.jp/records/1362
https://iwatemed.repo.nii.ac.jp/records/1362718f8250-b3ad-4051-8674-26d5b7902cc1
名前 / ファイル | ライセンス | アクション |
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KJ00004302030 (970.8 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-25 | |||||
タイトル | ||||||
タイトル | ミダゾラムによる鎮静時のBispectral Index変化とfMRIによる脳機能画像の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Changes to the bispectral index and regional cerebral blood flow in a sedative state, caused by midazolam administration | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
池田, 淳子
× 池田, 淳子 |
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著者名よみ |
イケダ, ジュンコ
× イケダ, ジュンコ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 31, 号 1, p. 32-43, 発行日 2006-04-25 |