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The purpose of this study is to investigate whether the inhibitory effect depends on the activation of cell bodies or passing fibers by the glutamate microinjection into the amygdala. The animals were anesthetized with N_2O-O_2 (2:1) and 0.5%-halothane, and immobilized with pancuronium bromide. The peripheral test stimulus (a single rectangular pulse of 2.0 msec in duration) was applied to the facial skin in the receptive field of nociceptive neurons, and the ipsilateral amygdaloid conditioning stimuli to the recording site were trains of 33 pulses (0.5 msec in duration, 100-300μA) delivered at 330Hz. Thirty-five wide dynamic range (WDR) neurons and 11 nociceptive specific (NS) neurons were recorded. Both neurons were distributed in the superficial layers of the caudal nucleus and diffusely throughout the dorsal part of the reticular subnucleus. The conditioning stimulation in the central nucleus, basomedial and basolateral nuclei markedly inhibited the activities in 13 of 17 nociceptive neurons (10 WDR and 3 NS neurons). The inhibitory effect was 68.0±15.3% (mean±S.D.) at maximum. Microinjection of 0.5M monosodium glutamate (5μl) into the amygdala resulted in inhibition of medullary nociceptive neurons (5 WDR and 2 NS neurons). These findings suggest that the excitation of cell bodies in the amygdala contribute to the inhibitory effects on the 2nd order nociceptive neurons. 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ラット扁桃体へのグルタメイト微量注入による延髄後角の侵害受容細胞に対する抑制効果
https://iwatemed.repo.nii.ac.jp/records/1423
https://iwatemed.repo.nii.ac.jp/records/1423a1c3f85c-85e2-4e30-9f29-c6987785c7d3
名前 / ファイル | ライセンス | アクション |
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KJ00004487749 (1.4 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-12-20 | |||||
タイトル | ||||||
タイトル | ラット扁桃体へのグルタメイト微量注入による延髄後角の侵害受容細胞に対する抑制効果 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inhibition of nociceptive neurons in the medullary dorsal horn by glutamate microinjection into the amygdala of the rat | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
山田, 裕之
× 山田, 裕之× 松本, 範雄 |
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著者名よみ |
ヤマダ, ヒロユキ
× ヤマダ, ヒロユキ× マツモト, ノリオ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 31, 号 3, p. 164-176, 発行日 2006-12-20 |