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A defect 6 mm in diameter was made in the cranium of 36 Wistar rats aged 16 weeks (6 animals per group). bFGF (1.0 and 10.0 μg) and physiological saline (control) were added to AGD with a water content of 81.8 ± 0.2%, and the discs were implanted in the bone defects. The animals were sacrificed after 4 and 8 weeks, and evaluated. Regenerated bone was evaluated by X-ray photodensitometry using an aluminum step wedge and imaging plate JP) and based on the CT concentration (pixel concentration) and volume on microfocus X-ray CT. Photodensitometry showed that bFGF promoted bone regeneration with time in a concentration-dependent manner. Microfocus X-ray CT also detected similar changes in the pixel concentration in the regenerated region and the regenerated bone volume, clarifying that bFGF promoted bone regeneration. The relative aluminum concentration measured by photodensitometry and the pixel concentration measured by microfocus X-ray CT were correlated. It was revealed that microfocus X-ray CT can non-invasively evaluate regenerated bone, and is capable of quantitative and 3 -dimensional analyses. 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bFGF含有酸性ゼラチンを用いた骨再生モデルに対するX線学的検討
https://iwatemed.repo.nii.ac.jp/records/1453
https://iwatemed.repo.nii.ac.jp/records/1453fa3c1ca5-abc9-4a98-a98c-156eee0877b0
名前 / ファイル | ライセンス | アクション |
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KJ00004579606 (2.1 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-04-25 | |||||
タイトル | ||||||
タイトル | bFGF含有酸性ゼラチンを用いた骨再生モデルに対するX線学的検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | X-ray study of bone regeneration model using basic FGF-incorporated acidity gelatin | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
澤田, 剛光
× 澤田, 剛光 |
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著者名よみ |
サワダ, タケミツ
× サワダ, タケミツ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 32, 号 1, p. 11-24, 発行日 2007-04-25 |