WEKO3
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A previous study using in situ staining with a DNA-binding fluorescent dye (Hoechst 33258) demonstrated numerous small granular structures in the cytoplasm of the epithelial cells in leukoplakia, suggesting that microorganisms were present. Furthermore, it was speculated that the microorganisms in the epithelial cells were oral mycoplasma. In this study, to examine intracellular infection by mycoplasma in epithelial cells with leukoplakia, fluorescent immunohistochemistry was performed using anti-mycoplasma rabbit polyclonal antibodies. Thirty-one formalin-fixed, paraffin-embedded specimens of leukoplakia without epithelial dysplasia and 19 epithelial dysplasia specimens were examined. Normal appearing mucosa specimens were used as controls. In all specimens of leukoplakia without epithelial dysplasia, numerous small granular fluorescing structures were observed within the cytoplasm of epithelial cells. In 10 of 19 (52.3%) specimens with epithelial dysplasia, fluorescing structures were observed, but were not observed in the remaining 9 specimens. In normal-appearing mucosa specimens, a few or no fluorescing structures were observed. These findings strongly suggest that mycoplasma infection is related to hyperkeratosis of oral mucosa. 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口腔白板症上皮細胞におけるマイコプラズマ感染 : 抗マイコプラズマ・ウサギポリクローナル抗体を用いた蛍光免疫組織化学による検討
https://iwatemed.repo.nii.ac.jp/records/1536
https://iwatemed.repo.nii.ac.jp/records/15360dd9ee92-659c-4e25-927e-232f97d94516
名前 / ファイル | ライセンス | アクション |
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KJ00004902646 (3.5 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-04-25 | |||||
タイトル | ||||||
タイトル | 口腔白板症上皮細胞におけるマイコプラズマ感染 : 抗マイコプラズマ・ウサギポリクローナル抗体を用いた蛍光免疫組織化学による検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Mycoplasma infection in the epithelial cells of oral leukoplakia : detection by fluorescent immunohistochemistry using anti-mycoplasma rabbit polyclonal antibody | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
長澤, 大
× 長澤, 大 |
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著者名よみ |
ナガサワ, ダイ
× ナガサワ, ダイ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 33, 号 1, p. 1-17, 発行日 2008-04-25 |