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Concomitant administration of IL-12 and IL-18 may increase the effects. In this study, we used squamous cell carcinoma that spontaneously developed in inbred strain WHT/Ht mice. IL-12 and IL-18 were administered alone or concomitantly to tumor-bearing mice, and the antitumor effects of the cytokines were compared. As a result, the tumor growth was inhibited by IL-12 and IL-18, and prolonged survival. IFN- γ production was also increased. On measurement of cytotoxic activity and NK activity, administration of IL-12 and IL-18 increased the activities. All these effects were stronger in the concomitant administration group than the single administration groups, but body weight decreased in the concomitant administration group. 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IL-12/IL-18のマウス扁平上皮癌に対する抗腫瘍効果の検討
https://iwatemed.repo.nii.ac.jp/records/1607
https://iwatemed.repo.nii.ac.jp/records/160782a6fbb1-f3e7-412f-b37d-d7bea74477d5
名前 / ファイル | ライセンス | アクション |
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KJ00002373825 (769.2 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-04-26 | |||||
タイトル | ||||||
タイトル | IL-12/IL-18のマウス扁平上皮癌に対する抗腫瘍効果の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Antitumor effect of IL-12/IL-18 against murine squamous cell carcinoma. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
著者名(日) |
北畠, 顕良
× 北畠, 顕良 |
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著者名よみ |
キタバタケ, アキラ
× キタバタケ, アキラ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 27, 号 1, p. 13-23, 発行日 2002-04-26 |