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However, the relationship between nodule formation of the pulp cells and apoptosis has not yet been clarified. The purpose of this study was to confirm the role of apoptosis in the nodule formation of dental pulp cells in vitro. Dental pulp cells in explant culture originating from a patient with periodontitis were cultured from 5 to 9 limes in D-MEM. The cells were cultured for 4 weeks in the absence or presence of a Caspase-3 inhibitor, Caspase-3 /CPP32 Inhibitor-CHO, in order to examine its effect no inhibition of apoptosis of dental pulp cells. The formation of nodules by dental pulp cells was observed by phase contrast microscope in the fourth week of culture, and the total numbers of nodules in a definite field were counted. Apoptosis of dental pulp cells in nodules was detected with a Caspase-3 detection kit by FITC, and was observed by laser microscope. Statistical analysis on changes of the nodule numbers was done by paired or unpaired t-test. Results showed that the number of nodules formed in the absence or presence of the caspase-3 inhibitor increased every week during four weeks (P\u003c0.01). However, the number of nodules in the presence of the caspase-3 inhibitor was significantly less than that of the control culture at three and four weeks (P\u003c0.05). These results indicate that apoptosis of dental pulp cells in vitro occurres along nodule formation and precedes calcification.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Periodontology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "短報"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科保存学第二講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2002-04-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002373829.pdf", "filesize": [{"value": "312.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 312200.0, "url": {"label": "KJ00002373829", "url": "https://iwatemed.repo.nii.ac.jp/record/1611/files/KJ00002373829.pdf"}, "version_id": "7500524e-f06f-4666-b3ed-c8af070b2533"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "dental pulp cell", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nodule formation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "calcification", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "apoptosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "培養歯髄細胞のnodule形成におけるアポトーシスの関与", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "培養歯髄細胞のnodule形成におけるアポトーシスの関与"}, {"subitem_title": "Apoptosis of dental pulp cells in nodule formation in vitro.", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["121", "395"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1611", "pubdate": {"attribute_name": "公開日", "attribute_value": "2002-04-26"}, "publish_date": "2002-04-26", "publish_status": "0", "recid": "1611", "relation": {}, "relation_version_is_last": true, "title": ["培養歯髄細胞のnodule形成におけるアポトーシスの関与"], "weko_shared_id": 5}
培養歯髄細胞のnodule形成におけるアポトーシスの関与
https://iwatemed.repo.nii.ac.jp/records/1611
https://iwatemed.repo.nii.ac.jp/records/1611ed4f82ff-d3e0-40a4-a829-f6f1e87a80e2
名前 / ファイル | ライセンス | アクション |
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KJ00002373829 (312.2 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-04-26 | |||||
タイトル | ||||||
タイトル | 培養歯髄細胞のnodule形成におけるアポトーシスの関与 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Apoptosis of dental pulp cells in nodule formation in vitro. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
短報 | ||||||
著者名(日) |
矢菅, 隆利
× 矢菅, 隆利 |
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著者名よみ |
ヤスゲ, タカトシ
× ヤスゲ, タカトシ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 27, 号 1, p. 44-48, 発行日 2002-04-26 |