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Like P. gingivalis, a major pathogen of adult periodontitis, P. endodontalis is asaccharolytic and forms black-pigmented colonies on enriched blood agar plates. However, pathogenic factors and pathological potential of this microbe have been poorly characterized. In this study, we assessed the adhesive abilities of P. endodontalis to gingival epithelial cell, and investigated whether P. endodontalis has a major fimbrial component of fimbrilin similar to that of P. gingivalis. Furthermore, the proteolytic activities of P. endodontalis were examined. The results indicated that P. endodontalis significantly adhered to a mouse gingival epithelial cell line, GE1, although the adhesive ability was lower than that of P. gingivalis. The electron microscopic investigations showed scarcely any fimbriae in P. endodontalis. Furthermore, PCR and the DNA-DNA hybridization analysis for the gene encoding fimbrilin (fimA) of P. gingivalis revealed that P. endodontalis did not have fimA or fimA-related genes, which could account for the lesser adhesive ability of P. endodontalis to gingival epithelial cells. The hydrolyzing profile toward various synthetic peptides showed that the spectrum of proteolytic activities of P. endodontalis was markedly different from that of P. gingivalis. Thus, the present findings indicate that P. endodontalis has a different adhesion mechanism from P. gingivalis fimbriae, and has a different spectrum of proteolytic activities from that of P. gingivalis, which may lead to the specific pathological potential of the organisms in periapical lesions in humans.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Operative Dentistry and Endodontics, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科保存学第一講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2002-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002373615.pdf", "filesize": [{"value": "781.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 781800.0, "url": {"label": "KJ00002373615", "url": "https://iwatemed.repo.nii.ac.jp/record/1652/files/KJ00002373615.pdf"}, "version_id": "3bc7b03a-9798-496a-8bcd-138a331fd5e3"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Porphyromonas endodontalis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pathogenic factors", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "fimA", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adhesion", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "protease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Porphyromonas endodontalisの病原因子の解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Porphyromonas endodontalisの病原因子の解析"}, {"subitem_title": "Pathogenic factors of Porphyromonas endodontalis", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["122", "397"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1652", "pubdate": {"attribute_name": "公開日", "attribute_value": "2002-12-24"}, "publish_date": "2002-12-24", "publish_status": "0", "recid": "1652", "relation": {}, "relation_version_is_last": true, "title": ["Porphyromonas endodontalisの病原因子の解析"], "weko_shared_id": 5}
Porphyromonas endodontalisの病原因子の解析
https://iwatemed.repo.nii.ac.jp/records/1652
https://iwatemed.repo.nii.ac.jp/records/165203a24269-f4aa-4627-8fd7-934d01e7df3e
名前 / ファイル | ライセンス | アクション |
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KJ00002373615 (781.8 kB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-12-24 | |||||
タイトル | ||||||
タイトル | Porphyromonas endodontalisの病原因子の解析 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathogenic factors of Porphyromonas endodontalis | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
昆, 麻子
× 昆, 麻子 |
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著者名よみ |
コン, アサコ
× コン, アサコ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 27, 号 3, p. 187-196, 発行日 2002-12-24 |