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The isometric tension and intracellular Ca^2+ concentration ( [Ca^2+]i) by the fura-2 microfluorometric methods were measured simultaneously, and from them we tried to deduce the depressing mechanism of lidocaine (1.0× 10^-3M) on the contraction. The results were obtained as follows:(1) Lidocaine depressed the increase of contraction and [Ca^2+]i induced by KCl and adrenaline in a concentration-dependent manner. (2) Lidocaine depressed the increase of contraction and [Ca^2+]i induced by adrenaline in normal physiological salt solution after depletion of the intracellular Ca^2+-sensitive Ca^2+ store. (3) Lidocaine depressed the increase of contraction and [Ca^2+]i induced by adrenaline in Ca^2+-free physiological salt solution. (4) Lidocaine had no effect on Ca^2+ induced Ca^2+ release(CICR) by caffein. These results suggest the following conclusions as follows, 1. Lidocaine depresses influx of Ca^2+ through VDCC and RACC. 2. Lidocaine inhibits the increase of [Ca^2+]i through IP_3 processes. 3. Lidocaine has no effect on CICR.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Dental Anesthesiology, School of Dentistry, Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Dental Anesthesiology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Original"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科麻酔学講座"}, {"subitem_text_value": "岩手医科大学歯学部歯科麻酔学講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2002-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002373619.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "KJ00002373619", "url": "https://iwatemed.repo.nii.ac.jp/record/1656/files/KJ00002373619.pdf"}, "version_id": "4486b8c6-b88f-4c7e-a474-beea0dbab609"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "porcine lingual artery", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lidocaine", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adrenaline", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "tension", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intracellular Ca^2+ concentration", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ブタ舌動脈血管平滑筋におけるアドレナリン収縮に対するリドカインの抑制機序の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ブタ舌動脈血管平滑筋におけるアドレナリン収縮に対するリドカインの抑制機序の検討"}, {"subitem_title": "Effects of lidocaine on changes in intracellular Ca^2+ concentration and tension of the smooth muscle induced by adrenaline in porcine lingual arteries", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["118", "397"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1656", "pubdate": {"attribute_name": "公開日", "attribute_value": "2002-12-24"}, "publish_date": "2002-12-24", "publish_status": "0", "recid": "1656", "relation": {}, "relation_version_is_last": true, "title": ["ブタ舌動脈血管平滑筋におけるアドレナリン収縮に対するリドカインの抑制機序の検討"], "weko_shared_id": 5}
ブタ舌動脈血管平滑筋におけるアドレナリン収縮に対するリドカインの抑制機序の検討
https://iwatemed.repo.nii.ac.jp/records/1656
https://iwatemed.repo.nii.ac.jp/records/1656c8cfef12-711c-4b80-bdc2-0c1f3cfcccad
名前 / ファイル | ライセンス | アクション |
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KJ00002373619 (1.1 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2002-12-24 | |||||
タイトル | ||||||
タイトル | ブタ舌動脈血管平滑筋におけるアドレナリン収縮に対するリドカインの抑制機序の検討 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effects of lidocaine on changes in intracellular Ca^2+ concentration and tension of the smooth muscle induced by adrenaline in porcine lingual arteries | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
畠山, 忠臣
× 畠山, 忠臣× 佐藤, 健一 |
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著者名よみ |
ハタケヤマ,タダオミ,サトウ,ケンイチ
× ハタケヤマ,タダオミ,サトウ,ケンイチ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 27, 号 3, p. 219-229, 発行日 2002-12-24 |