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This study evaluated bone regeneration using rhBMP-2 in bone defects of the mandible. Bone defects 20 mm wide were surgically created in mandibular bones of adult male beagles and implants were placed into the bone defects. Experimental groups comprised a rhBMP-2 (+) group, a rhBMP-2 (-) group and a control group (no bone defects created). Animals were killed 12 weeks postoperatively, followed by quantitative, radiological and histological evaluations. Bone mineral measurement using dual energy X-ray absorptiometry (DEXA) revealed significant differences between the rhBMP-2 (+) group and, the rhBMP-2 (-) and control groups in bone mineral density (BMD) (p\u003c0.01). Elementary analysis using particle induced X-ray emission (PIXE) revealed significant differences between the rhBMP-2 (+) group and, the rhBMP-2 (-) and control groups in concentrations of Mg and Ca (p\u003c0.05, p\u003c0.01). Using soft X-ray, the rhBMP-2 (+) group displayed better absorption of implants and new bone formation than the rhBMP-2 (-) group. Using microfocus X-ray CT, the rhBMP-2 (+) group displayed better absorption of implants, bone regeneration and internal structure of mandible than the rhBMP-2 (-) group. In histology, the rhBMP-2 (+) group displayed better absorption of implants and new bone formation than the rhBMP-2 (-) group. 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骨形成蛋白質(BMP)を用いた顎骨再生に関する実験的研究
https://iwatemed.repo.nii.ac.jp/records/1686
https://iwatemed.repo.nii.ac.jp/records/16861a997e2a-1f8d-4b9b-bd5b-0b2b09c3f67d
名前 / ファイル | ライセンス | アクション |
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KJ00002373649 (1.9 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2003-04-21 | |||||
タイトル | ||||||
タイトル | 骨形成蛋白質(BMP)を用いた顎骨再生に関する実験的研究 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Experimental study of bone regeneration using bone morphogenetic protein (BMP) | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Original | ||||||
著者名(日) |
中谷, 寛之
× 中谷, 寛之 |
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著者名よみ |
ナカタニ, ヒロユキ
× ナカタニ, ヒロユキ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 28, 号 1, p. 16-26, 発行日 2003-04-21 |