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However, its overproduction induced by some bacterial antigens could cause damage to host tissues and cellular DNA. We have previously reported a novel bioactive antigen (SAA) from a culture supernatant of Streptococcus anginosus that induces NO synthesis by murine peritoneal exudate cells (PEC). In this study, I performed a further assessment of SAA-induced NO synthesis by PEC. The results indicated that SAA stimulated the macrophages in PEC as well as a murine macrophage cell line, J774.1, to produce NO with the accumulation of inducible NO synthase (iNOS) mRNA. SAA also stimulated the non-macrophage cells in PEC to produce IFN- γ, however, the endogenous IFN-γ was not involved in the SAA-induced NO synthesis and iNOS mRNA accumulation by the macrophages. Further, phosphorylation of both p38 and ERK1/2 mitogen-activated protein (MAP) kinase was observed in macrophages by the stimulation with SAA but p38 MAP kinase pathway could solely correlate with SAA-induced NO synthesis. Thus, the present results suggest that S. anginosus, by a bioactive antigen, SAA, could stimulate macrophages through p38 MAP kinase nathwav to induce NO svnthesis without heln of the endogenous TFN-γ.", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Oral Microbiology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部口腔微生物学講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2004-04-26"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002373742.pdf", "filesize": [{"value": "1.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1000000.0, "url": {"label": "KJ00002373742", "url": "https://iwatemed.repo.nii.ac.jp/record/1778/files/KJ00002373742.pdf"}, "version_id": "04aee179-4109-4c2a-9d33-42be20ec196a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Streptococcus anginosus", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "nitric oxide synthesis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "peritoneal exudate cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "macrophages, MAP kinase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Streptococcus anginosus由来抗原によるマウス腹腔滲出細胞からのNO産生誘導機構", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Streptococcus anginosus由来抗原によるマウス腹腔滲出細胞からのNO産生誘導機構"}, {"subitem_title": "Nitric oxide synthesis in marine peritoneal exudate cells stimulated with a Streptococcus anginosus antigen", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["128", "403"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1778", "pubdate": {"attribute_name": "公開日", "attribute_value": "2004-04-26"}, "publish_date": "2004-04-26", "publish_status": "0", "recid": "1778", "relation": {}, "relation_version_is_last": true, "title": ["Streptococcus anginosus由来抗原によるマウス腹腔滲出細胞からのNO産生誘導機構"], "weko_shared_id": 5}
Streptococcus anginosus由来抗原によるマウス腹腔滲出細胞からのNO産生誘導機構
https://iwatemed.repo.nii.ac.jp/records/1778
https://iwatemed.repo.nii.ac.jp/records/177812c42ed4-e1ae-4def-aefe-e751ed5e1b4a
名前 / ファイル | ライセンス | アクション |
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KJ00002373742 (1.0 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2004-04-26 | |||||
タイトル | ||||||
タイトル | Streptococcus anginosus由来抗原によるマウス腹腔滲出細胞からのNO産生誘導機構 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Nitric oxide synthesis in marine peritoneal exudate cells stimulated with a Streptococcus anginosus antigen | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
著者名(日) |
山浦, 千春
× 山浦, 千春 |
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著者名よみ |
ヤマウラ, チハル
× ヤマウラ, チハル |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 29, 号 1, p. 3-14, 発行日 2004-04-26 |