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Nitric oxide (NO) production may contribute to these processes. NO production in the tumor depends on the iNOS. 1400W is the most selective iNOS inhibitor and strongly prevents NO production by the iNOS. In the present study, the effect of 1400W on tumor-induced angiogenesis and tumor proliferation was examined using a weakly immunogenic squamous cell carcinoma of the WHT/Ht mouse. 1400W inhibited the angiogenesis induced by the murine tumor dose-dependently, and the number of blood vessels orientated towards the intradermal tumor was maximally reduced by 62.5% compared to the control. In the tumor proliferation assay, 1400W significantly inhibited proliferation of the subcutaneously inoculated tumor, and reduced the tumor volume by 60.0% (20mg/kg) and 75.7% (lOmg/kg) compared to the control. Subcutaneously inoculated tumors were observed by the Immunohistochemistry and Western blot analysis, and iNOS and VEGF expression was lowered with administration of 1400W compared to the control. 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マウス扁平上皮癌の増殖に対するiNOS阻害薬の影響
https://iwatemed.repo.nii.ac.jp/records/1780
https://iwatemed.repo.nii.ac.jp/records/1780502fd4ec-2c61-4040-8d47-657a9ae17235
名前 / ファイル | ライセンス | アクション |
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KJ00002373744 (1.6 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2004-04-26 | |||||
タイトル | ||||||
タイトル | マウス扁平上皮癌の増殖に対するiNOS阻害薬の影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of iNOS inhibitor on proliferation of murine squamous cell carcinoma | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
著者名(日) |
堤, 陽一
× 堤, 陽一 |
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著者名よみ |
ツツミ, ヨウイチ
× ツツミ, ヨウイチ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 29, 号 1, p. 24-32, 発行日 2004-04-26 |