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The following results were obtained 1 Complete cerebral ischemia increased brain choline contents rapidly and remarkably for 10 minutes After 10 minutes, the rate of increase of brain choline contents suddenly fell. 2 The increased level of choline contents by complete cerebral ischemia differed among the brain regions (cerebral cortex, hippocampus, medulla oblongata, cerebellum) tested 3 Selective ischemia increased choline contents in the cerebral cortex and hippocampus but not in the medulla oblongata or cerebella. 4. As with complete ischemia, hypoxia induced by N_2 gas inhalation increased choline contents in all brain regions. 5. Hypoglycemia induced by insulin administration did not increase brain choline contents However, the ischemia under a hypoglycemia state produced a greater choline increase than ischemia alone 6 Complete cerebral ischemia decreased the contents of both phosphatidylcholme (PtdCh) and glycerophosphocholine (GlyCh) in the mouse brain. The present results suggest that a main cause for the ischemic increase of brain choline contents is hypoxia by cessation of blood flow, and a low energy state caused by hypoglycemia partly contributes to this increase Furthermore, it is suggested that the ischemic increase of brain choline depends on the choline accumulation that results from decomposition of both PtdCh and GlyCh", "subitem_description_type": "Other"}]}, "item_2_source_id_13": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00017474", "subitem_source_identifier_type": "NCID"}]}, "item_2_text_10": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Dental Anesthesiology, School of Dentistry, Iwate Medical University"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Dental Pharmacology, School of Dentistry, Iwate Medical University"}]}, "item_2_text_2": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_text_value": "研究"}]}, "item_2_text_3": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Oliginal"}]}, "item_2_text_9": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "岩手医科大学歯学部歯科麻酔学講座"}, {"subitem_text_value": "岩手医科大学歯学部歯科薬理学講座"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2004-12-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00002373794.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensefree": "Creative Commons : 表示 - 非営利 - 改変禁止", "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "KJ00002373794", "url": "https://iwatemed.repo.nii.ac.jp/record/1830/files/KJ00002373794.pdf"}, "version_id": "90fd6348-ab0a-491c-89a2-a2b45e45ec3f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "cerebral ischemia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hypoxia, hypoglycemia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "choline metabolism", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "mouse", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "マウス脳内コリン代謝に及ぼす虚血の影響", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "マウス脳内コリン代謝に及ぼす虚血の影響"}, {"subitem_title": "Effect of cerebral ischemia on chohne metabolism in the mouse brain", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "5", "path": ["118", "405"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/1830", "pubdate": {"attribute_name": "公開日", "attribute_value": "2004-12-20"}, "publish_date": "2004-12-20", "publish_status": "0", "recid": "1830", "relation": {}, "relation_version_is_last": true, "title": ["マウス脳内コリン代謝に及ぼす虚血の影響"], "weko_shared_id": 5}
マウス脳内コリン代謝に及ぼす虚血の影響
https://iwatemed.repo.nii.ac.jp/records/1830
https://iwatemed.repo.nii.ac.jp/records/1830cd2cfad3-b7e2-496b-ab0e-34cfc842b245
名前 / ファイル | ライセンス | アクション |
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KJ00002373794 (1.2 MB)
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Creative Commons : 表示 - 非営利 - 改変禁止
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Item type | 紀要論文(ELS) / Departmental Bulletin Paper(1) | |||||
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公開日 | 2004-12-20 | |||||
タイトル | ||||||
タイトル | マウス脳内コリン代謝に及ぼす虚血の影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of cerebral ischemia on chohne metabolism in the mouse brain | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
記事種別(日) | ||||||
研究 | ||||||
記事種別(英) | ||||||
en | ||||||
Oliginal | ||||||
著者名(日) |
根本, 光
× 根本, 光× 村井, 繁夫 |
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著者名よみ |
ネモト, アキラ
× ネモト, アキラ× ムライ, シゲオ |
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雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00017474 | |||||
書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 29, 号 3, p. 236-249, 発行日 2004-12-20 |