WEKO3
アイテム
{"_buckets": {"deposit": "73ec8b13-a9a3-449c-824d-3ca2a1a02ea8"}, "_deposit": {"created_by": 3, "id": "2708", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "2708"}, "status": "published"}, "_oai": {"id": "oai:iwatemed.repo.nii.ac.jp:00002708", "sets": ["79", "124"]}, "author_link": ["8842", "8845", "8843", "8844"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "150", "bibliographicPageStart": "142", "bibliographicVolumeNumber": "10", "bibliographic_titles": [{}, {"bibliographic_title": "Journal of Oral Tissue Engineering", "bibliographic_titleLang": "en"}]}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "破骨細胞の馴化培地中に存在する細胞外微小胞におけるマイクロRNA(miRNA)の発現について検討した。著者らの先行研究において破骨細胞形成に重要と思われたlet-7e、miR-21、miR-33、miR-155、miR-210、miR-223、miR-378、miR-1224の発現を、RT-PCR法を用いて調べた。その結果、破骨細胞の細胞外微小胞にはmiR-378、miR-210、miR-21が極めて高レベルに発現していたが、miR-33やmiR-1224の有意な発現は認めなかった。以上より、破骨細胞は細胞内miRNAのうちの特定のmiRNAを含む微小胞を細胞外に分泌することが示唆された。", "subitem_description_type": "Abstract"}, {"subitem_description": "Bone is one of the most important oral tissues. Osteoclasts play important roles in bone tissue engineering. Previously, we profiled microRNA (miRNA) expression during osteoclastogenesis using microarrays. miRNAs are small, noncoding RNAs that are involved in various biological processes, including cellular differentiation, proliferation, apoptosis, and organ development. Recently, the presence of miRNAs in extracellular microvesicles was reported. It is not known whether osteoclasts secrete extracellular microvesicles containing miRNAs. We investigated miRNA expression in extracellular microvesicles in conditioned medium of cultured osteoclasts using RT-PCR. Specifically, we investigated eight miRNAs deemed important for osteoclastogenesis in our previous study: let-7e, miR-21, miR-33, miR-155, miR-210, miR-223, miR-378, and miR-1224. Of these, the expression levels of miR-378, miR-210, and miR-21 were very high, while no significant miR-33 or miR-1224 expression was detected. These results suggest that osteoclasts secrete extracellular microvesicles containing specific miRNAs, but that they do not contain the entire set of intracellular miRNAs. ", "subitem_description_type": "Abstract"}]}, "item_10001_heading_23": {"attribute_name": "見出し", "attribute_value_mlt": [{"subitem_heading_banner_headline": "統合基礎講座", "subitem_heading_headline": "解剖学(機能)", "subitem_heading_language": "ja"}]}, "item_10001_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "権利:日本再生歯科医学会"}, {"subitem_rights": "出典:Journal of Oral Tissue Engineering"}, {"subitem_rights": "利用は著作権の範囲内に限られる"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1348-9623", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "鍵谷, 忠慶"}, {"creatorName": "カギヤ, タダヨシ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "8842", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平, 雅之"}, {"creatorName": "タイラ, マサユキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "8843", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tadayoshi, Kagiya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8844", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Taira", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "8845", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2014-04-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "B01201303TK.pdf", "filesize": [{"value": "324.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_11", "mimetype": "application/pdf", "size": 324700.0, "url": {"label": "B01201303TK", "url": "https://iwatemed.repo.nii.ac.jp/record/2708/files/B01201303TK.pdf"}, "version_id": "d9227130-fdbe-4cc0-bdea-1036d87fdca1"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "*エクソソーム", "subitem_subject_scheme": "Other"}, {"subitem_subject": "骨髄細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "培地", "subitem_subject_scheme": "Other"}, {"subitem_subject": "培養細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "*破骨細胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "分散分析", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マクロファージ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "RT-PCR法", "subitem_subject_scheme": "Other"}, {"subitem_subject": "破骨細胞分化因子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "*MicroRNAs", "subitem_subject_scheme": "Other"}, {"subitem_subject": "*小胞", "subitem_subject_scheme": "Other"}, {"subitem_subject": "マウス", "subitem_subject_scheme": "Other"}, {"subitem_subject": "歯学", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Macrophage Colony-Stimulating Factor", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "マウスの破骨細胞の細胞外微小胞におけるマイクロRNAの発現", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "マウスの破骨細胞の細胞外微小胞におけるマイクロRNAの発現"}, {"subitem_title": "Expression of MicroRNAs in the Extracellular Microvesicles of Murine Osteoclasts", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["79", "124"], "permalink_uri": "https://iwatemed.repo.nii.ac.jp/records/2708", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-04-23"}, "publish_date": "2014-04-23", "publish_status": "0", "recid": "2708", "relation": {}, "relation_version_is_last": true, "title": ["マウスの破骨細胞の細胞外微小胞におけるマイクロRNAの発現"], "weko_shared_id": -1}
マウスの破骨細胞の細胞外微小胞におけるマイクロRNAの発現
https://iwatemed.repo.nii.ac.jp/records/2708
https://iwatemed.repo.nii.ac.jp/records/2708d537df00-e085-4e05-8320-8fbdadfcb9a0
名前 / ファイル | ライセンス | アクション |
---|---|---|
B01201303TK (324.7 kB)
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-04-23 | |||||
タイトル | ||||||
タイトル | マウスの破骨細胞の細胞外微小胞におけるマイクロRNAの発現 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Expression of MicroRNAs in the Extracellular Microvesicles of Murine Osteoclasts | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
鍵谷, 忠慶
× 鍵谷, 忠慶× 平, 雅之× Tadayoshi, Kagiya× Masayuki, Taira |
|||||
書誌情報 |
en : Journal of Oral Tissue Engineering 巻 10, 号 3, p. 142-150, 発行日 2013-03 |
|||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1348-9623 | |||||
権利 | ||||||
権利情報 | 権利:日本再生歯科医学会 | |||||
権利 | ||||||
権利情報 | 出典:Journal of Oral Tissue Engineering | |||||
権利 | ||||||
権利情報 | 利用は著作権の範囲内に限られる | |||||
見出し | ||||||
大見出し | 統合基礎講座 | |||||
小見出し | 解剖学(機能) | |||||
言語 | ja |