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"マウスにおける自発運動並びに脳内monoamine関連物質に及ぼす絶食の影響について検討した.1)絶食はマウスのVMA(垂直運動)を著明に増大し,HMA(水平運動)を軽度に増大したが,WRA(回転カゴ運動)を増大しなかった.2)絶食マウスへのmethamphetamine (2 mg/kg)投与の場合,VMAはhaloperidol (0.25 mg/kg)前処置のある・なしにかかわらず増大し,HMAはhaloperidolの前処置で軽度減少し,WRAでは軽度増大した.3)絶食マウスへのapomorphine (0.1および0.5 mg/kg)投与の場合,VMA, HMAおよびWRAはhaloperidolの前処置のある・なしにかかわらず,実験の初期に減少し,用量的二面性を示した.4)絶食マウスのcage climbing量は飽食マウスのそれらと同程度の値を示した.5)絶食マウスの脳内monoamine関連物質含量の測定において,線条体ではDAの増大,3-MTの減少,NEの増大並びに5-HTおよび5-HIAAの増大が,視床下部ではMHPGの増大が,側坐核では3-MTの減少がみられた", "subitem_description_type": "Abstract"}]}, "item_10002_heading_23": {"attribute_name": "見出し", "attribute_value_mlt": [{"subitem_heading_banner_headline": "統合基礎講座", "subitem_heading_headline": "薬理学(病態)", "subitem_heading_language": "ja"}]}, "item_10002_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "岩手医科大学歯学会"}]}, "item_10002_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": 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マウスにおけるmethamphetamineおよびapomorphine誘導運動並びに脳内monoamine代謝に及ぼす絶食の影響
https://iwatemed.repo.nii.ac.jp/records/3490
https://iwatemed.repo.nii.ac.jp/records/349093d7e3a0-bbca-46cd-9b7b-3191c199b5af
名前 / ファイル | ライセンス | アクション |
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A021230241 (796.0 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2014-06-19 | |||||
タイトル | ||||||
タイトル | マウスにおけるmethamphetamineおよびapomorphine誘導運動並びに脳内monoamine代謝に及ぼす絶食の影響 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The effect of fasting on the methamphetamine and apomorphine-induced locomotor activities and on the metabolism of brain monoamines in the mouse. | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
菊地, 康
× 菊地, 康× Kikuchi, Yasushi |
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書誌情報 |
岩手医科大学歯学雑誌 en : Dental journal of Iwate Medical University 巻 12, 号 3, p. 241-253, 発行日 1987-11 |
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出版者 | ||||||
出版者 | 岩手医科大学歯学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-1311 | |||||
権利 | ||||||
権利情報 | rights:岩手医科大学歯学会 | |||||
権利 | ||||||
権利情報 | rights:本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.20663/iwateshigakukaishi.12.3_241 | |||||
見出し | ||||||
大見出し | 統合基礎講座 | |||||
小見出し | 薬理学(病態) | |||||
言語 | ja |